Background: Poor executive functions are potentially risky for psychopathology and can also reduce response to treatment. This study was conducted to investigate the moderating role of executive functions in the relationship between anxiety and depression symptoms and response to drug therapy.
Methods: the method was a correlation. The statistical population of this study was adult outpatients with anxiety disorders and depression who were referred to psychiatric clinics of Bojnourd city. One hundred and sixty-four participants completed the Outcome Questionnaire, Brief Symptom Inventory, and Behavior Rating Inventory of Executive Function.
Results: The findings showed that problems of executive functions and anxiety and depression symptoms predicted weak response to treatment(p <.0001) Also, the results of moderating regression analysis showed that problems of executive functions significantly moderate the relationship of anxiety symptoms and response to treatment (p <.0001) while they do not moderate significantly relationship of depression symptoms and response to treatment (p>.05). The results also showed that a longer course of the disease and the comorbidity of depression and anxiety reduce the response to treatment (p <.05).
Conclusion: Poor performance in executive functions, a longer course of the disease, and the comorbidity of anxiety and depression disorders can reduce the response to treatment in patients.