Document Type : Original Articles

Authors

1 Student research committee, Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.

2 1- Bone and Joint Diseases Research Center, department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran. 2- Shiraz Geriatric Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

3 department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.

4 Department of physical medicine and rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran.

10.30476/jrsr.2022.90605.1150

Abstract

Abstract:                
Knee osteoarthritis (KOA) is a common public health disease with an increasing prevalence. It is one of the leading causes of disability, especially in the elderly. Intra-articular hypertonic dextrose prolotherapy is one of the therapies used for KOA. There have been some articles showing that patients receiving intra-articular normal saline as a control group of the article had improvement as well. The aim of this randomized clinical trial study was to evaluate the efficacy of intra-articular hypertonic saline in comparison with hypertonic dextrose prolotherapy in treatment of KOA. 54 patients with KOA were randomized in two groups: hypertonic dextrose (28 patients) and hypertonic saline groups (26 patients). All patients received three intra-articular injections of either hypertonic dextrose or hypertonic saline at two weeks intervals. The visual analogue pain scale (VAS), Oxford knee scale (OKS), and Western Ontario McMaster University Osteoarthritis Index (WOMAC) questionnaire were the outcome measures which were evaluated before, 2 and 4 weeks after the injections. The data were analyzed using t-test and repeated measurement tests. Both groups showed improvements in outcome measures after 2 and 4 weeks of intervention. However, no statistically significant difference was noted between the two groups. We concluded that the intra-articular injection of hypertonic dextrose and hypertonic saline are both effective in the management of KOA. Hypertonic saline can be considered as another medical agent in management of KOA. However, further studies are suggested to evaluate its long-term effects

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