Hamidreza Farpour; Elham Sheybani; Elahe Keshavarzi
Volume 9, Issue 1 , March 2022, , Pages 23-29
Abstract
Background: The use of epidural steroid injection in spinal stenosis painmanagement has expanded greatly. Calcitonin is also effective in relievingneuropathic pain in spinal canal stenosis ...
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Background: The use of epidural steroid injection in spinal stenosis painmanagement has expanded greatly. Calcitonin is also effective in relievingneuropathic pain in spinal canal stenosis through the mechanisms of arterialdilation, anti-inflammation, anti-edema, and rises in beta endorphin levels. Thecurrent study was designed to evaluate the effect of mesotherapy with calcitonincompared with epidural steroid injection for pain relief and functionalimprovement in patients with lumbosacral canal stenosis.Methods: A total of 39 patients comparable in age and gender with signs andsymptoms of lumbosacral canal stenosis participated in this randomizedcontrol trial. Group A comprised patients receiving mesotherapy of 100 IUCalcitonin+Marcaine 0.5% (4 mL) in three repeated injections in the lumbosacralarea; group B received a single caudal epidural injection of Marcaine 0.5%(4 mL)+80 mg methyl prednisolone (2 mL) under the guide of a fluoroscope.Patients were evaluated before and 4 and 8 weeks after intervention using thevisual analog scale (VAS), Oswestry Disability Index (ODI), Quebec back paindisability scale (QBPD), and Ronald-Morris Disability Questionnaire (RMDQ).Results: Based on the VAS, ODI, QBPD, and RMDQ scales, a significantimprovement in pain and functional disability was observed in both groups 4and 8 weeks after intervention (P<0.05), which was comparable between the twogroups (P>0.05).Conclusion: Mesotherapy with calcitonin Marcaine is just as effective as caudalepidural steroid injection; considering its advantages, mesotherapy can be aproper alternative method for managing pain and functional impairment inpatients with lumbosacral canal stenosis.
