Document Type : Original Articles


1 Skull Base Research Center, Loghman Hakim Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2 Social Determinants of Health Research Center, Amir-al-Momenin Hospital,Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran

3 Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Background : We aimed to determine the quality of life(QoL) score before and after treatment in the patients with acromegaly.
 Methods: In this before-after study, AcroQol questionnaire was used to assess the QOL. Demographic, clinical manifestations and co-morbidity data, pituitary axis involvement, biochemical and hormonal component tests ,and HRQoL (Health-Related Quality of Life) before and after treatment (Endoscopic transsphenoidal surgery, medication , radiotherapy) were evaluated in the patients over 18. To compare the mean of continuous data independent t and Mann–Whitney test were used.  To compare the mean QOL score before and after study paired-t and Wilcoxon test performed.  The significance level was set up at p<0.05.
Results: Among 80 patients with acromegaly who underwent trans-sphenoid surgery with or without radiotherapy or medication therapy with somatostatin analogs 52(65%) entered the remission phase within 6 months. There was association between remission phase and female gender(p=0.004), lower growth hormone (GH) (p=0.04) so lower insulin like growth Factor-I (IGF1) after surgery(p=0.02) and no gonadal axis disorder after treatment(p<0.001) statistically. Also, there was significant association between not being in the remission phase and gonadal axis disorder before treatment (p=0.04). Qol score in all dimensions of the AcroQol questionnaire increased 6 months after treatment (p<0.001). Total AcroQol score after treatment was higher in remission group (p=0.03). As well as   psychological scale had a significant higher score both in the total scale (p<0.001) and in two subscale of appearance (p<0.001) and personal relationship (p=0.003).
Conclusion: Due to the importance of the Qol  in acromegaly patients, further studies in this field are recommended.