Document Type: Original Articles


1 Isfahan branch

2 isfahan


Background : Opioid use and addiction cause serious cardiovascular risks and also inflammation. Studies show that exercise and physical activity decrease cardiovascular risk factors. The purpose of this study was to determine the effect of aerobic exercise on some cardiovascular risk factors among opioid users.

Methods: To carry out this study, Thirty addicted men with mean age of (33.53±6.83y) and weight of (70.06±15/42kg) after (medical) screening were divided into experimental group (n=14) and control group (n=16). BMI, ICAM-1 and VCAM-1 were measured in both groups. At the start of the program experimental group was examined under influence of a treadmill aerobic program with intensity of 40%-50% maximal heart rate (MHR) that finally by increasing subject's fitness resulted in70%-80% MHR. All variables were measured in both groups after 8 weeks. independent t- test (p<0.05) were used for intra-group comparisons and inter- group comparisons respectively.

Results : Results showed that significant change was not seen in levels of ICAM-1 (p= 0.397), VCAM-1 (p= 0.521), BMI (p=0.223).

Conclusion : Although 8 weeks of aerobic exercise for ICOM-1 and VCAM-1 chemotactic indices were not sufficient and effective in opioid users, they reduced ICAM-1 and VCAM-1 in the training group

Keywords: Addiction, Adhesion molecules, Aerobic training